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Fatigue is a subjective unpleasant symptom, which incorporates total body feelings ranging from tiredness not relieved by rest or sleep to total exhaustion creating an unrelenting overall condition that interferes with the individual ability to function to their normal capacity. Fatigue is a commonly reported symptom.
Differential diagnosis includes:
  • Anaemia
  • Side effect of treatment
  • Immunotherapy induced endocrinopathy
  • Hormone disturbance e.g. thyroid dysfunction
  • Disease progression
  • Patient entering the dying phase
  • Depression/psychological problems


Are you a health professional looking for immediate guidance? 

UKONS Acute Oncology Initial Management may help


Cancer-related fatigue: ESMO Clinical Practice Guidelines for diagnosis and treatment
Weakness / Fatigue:   Scottish Palliative Care Guidelines

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